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Almaguer Cantu V, Garza-Gonzlez MT, de la Rosa JR, Loredo-Medrano JA

This microbial shift disrupts multiple gutbrain pathways simultaneously: these shifts coincided with gut barrier disruption (elevated serum endotoxin), triggering elevated hippocampal cytokines (IL-6, TNF-), which in turn suppress Tph2 expression and induce Tph2 hypermethylation (suggesting neuroinflammation and serotonergic suppression), ultimately manifesting as anxiety and depression-like behaviors (Buchenauer et al., 2023)

doi:10.1016/j.cell.2007.11.037

PMCID: PMC1130894